Untitled - Smoking and pre-eclampsia may cause fertility problems for offspring, study suggests

Smoking and pre-eclampsia may cause fertility problems for offspring, study suggests

Discoveries

Low levels of oxygen in the womb – which can be caused by smoking or conditions such as pre-eclampsia – may cause problems with fertility later in life, a study carried out in rats suggests. The research, led by scientists at the University of Cambridge, found that exposing fetuses to chronic hypoxia (low oxygen levels) during development led to them…

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Capture 1 - Researchers develop comprehensive new way to predict breast cancer risk

Researchers develop comprehensive new way to predict breast cancer risk

Scientists have created the most comprehensive method yet to predict a woman’s risk of breast cancer, according to a study led by researchers at the University of Cambridge. The study, funded by Cancer Research, is published today in Genetics in Medicine. They have a developed a way of calculating the risk of developing the disease by combining information on family…

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Capture - Slim people have a genetic advantage when it comes to maintaining their weight

Slim people have a genetic advantage when it comes to maintaining their weight

Discoveries

In the largest study of its kind to date, Cambridge researchers have looked at why some people manage to stay thin while others gain weight easily. They have found that the genetic dice are loaded in favour of thin people and against those at the obese end of the spectrum. More than six in ten adults in the UK are…

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Lack-of-the-two-tier-protection-system-leads-to-genomic-instability-and-mutations-in-blood-stem-cells

Uncovering how alcohol-derived metabolites damage the genome of stem cells

Discoveries

Previous work from KJ Patel’s group in the LMB’s PNAC Division revealed that aldehydes – such as acetaldehyde, a by-product of alcohol metabolism – can damage our DNA. Further research by the group showed that our cells are protected against these toxic aldehydes using a two-tier protection system: enzymes that remove these aldehydes (tier-1) and DNA repair that fixes the…

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