Lack-of-the-two-tier-protection-system-leads-to-genomic-instability-and-mutations-in-blood-stem-cells

Uncovering how alcohol-derived metabolites damage the genome of stem cells

22nd March 2018

Discoveries

Previous work from KJ Patel’s group in the LMB’s PNAC Division revealed that aldehydes – such as acetaldehyde, a by-product of alcohol metabolism – can damage our DNA. Further research by the group showed that our cells are protected against these toxic aldehydes using a two-tier protection system: enzymes that remove these aldehydes (tier-1) and DNA repair that fixes the…

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Statistical-methods-to-influence-HIV-policy

Statistical methods to influence HIV policy

30th October 2017

Discoveries

The work on evidence synthesis carried out by Daniela De Angelis and her team has contributed to the improvement of health care and overall public health by directly influencing policy in the area of HIV research. Their novel Multi-Parameter Evidence Synthesis (MPES) approach to estimating the HIV burden (De Angelis et al., 2014)  has been, and continues to be, the chosen…

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Long ward shot

Haematology unit is high-tech boost for patients

30th October 2017

Discoveries

An internationally renowned centre of clinical excellence at Cambridge University Hospitals has today (18 October) officially opened a high-tech facility which will double the number of patients it can treat. The Haematology Day Unit has moved from cramped premises on the tenth floor of Addenbrooke’s Hospital into a £1.5m state-of-the art ground floor facility opposite the main entrance. The unit…

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Wakeboarding Tom Shing

Non-beating heart donations increase transplantation at Papworth

30th October 2017

Discoveries

Two years after Europe’s first successful non beating heart transplant, the team at Papworth Hospital say they have proven that heart transplants from circulatory determined dead donors (DCD) are successful and can save many more patients on the ever-growing heart transplant waiting list. Doctors at the Cambridge hospital were the first in Europe to successfully perform the operation, in March…

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