Seminar: Adding new dimensions to invitro models of stroke and cSVD
Cambridge Cardiovascular Seminar Series: Adding new dimensions to invitro models of stroke and cSVD
Speaker: Dr Paul Holloway – Principle Investigator Radcliffe Department of Medicine, University of Oxford
When: Thursday 24 October 2024, 12:30pm light lunch followed by Seminar 1-2pm.
Where: Rooms 0.R100-102, VPD-HLRI, Cambridge Biomedical Campus, Papworth Road, Trumpington, Cambridge CB2 0BB.
Who is it for? Anyone involved in Cardiovascular Research
Stroke is the largest cause of adult disability in the world and despite over 1000 prospective neuroprotective agents having been investigated pre-clinically, none have yet translated to the clinic.
A number of key differences in the neurobiology of animal models and humans exist at both the cellular and molecular level, providing impetus to study human based systems. However, human in vitro stroke models are typically limited to simplistic monolayer cell cultures which fail to recapitulate the high level of structural organisation in the brain, 3D heterotypic cellular interactions and spatio-temporal localisation of injury.
In his lab Dr Holloway is using a range of techniques from iPSC and organoid cultures to microfluidic systems, to model and investigate specific aspects of stroke injury. Dr Holloway’s talk will give an overview of how these different approaches can be used to model neuronal circuits and gliovascular interactions, along with examples of how these systems can provide novel insights into disease mechanisms and therapeutic opportunities.
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