Innovation and excellence in science and health

Other laboratory resources & services

Cancer Molecular Diagnostic Laboratory- goal is to apply genomic methods to improve diagnosis, prognostication, patient stratification and disease monitoring
- consists of two sections focusing on epithelial and haematological malignancies
- protocols for high throughput sequencing and ctDNA approaches are being established
NIHR Cambridge Cell Phenotyping Hub- provides a wide variety of cytomics services e.g. sorting, analysis and imaging for material from cell lines, mouse or unscreened human blood and tissue samples for phenotypic and functional analysis in clinical and non-clinical environments
- aims to offer a GLP-standard phenotyping
- collects and disseminates technological and scientific expertise crucial for promoting and supporting patient-based research and for translating basic biological findings into clinical practice
- actively engaged in flow cytometry networking and regional, national and international societies
- equipped with state-of-the-art instrumentation, including high-speed cell sorters and multi-laser analysers (polychromatic laser configurations are crucial for multicolour phenotyping and support applications with a wide range of fluorochromes)
- also houses three microbiological safety cabinets for processing unscreened human samples, two confocal and two fluorescent microscopes
- operates collaboratively with the CIMR Flow Cytometry facility
Core Biochemical Assay LaboratoryThe Core Biochemical Assay Laboratory (CBAL) is a core facility whose staff are funded by the Cambridge Biomedical Research Centre. The laboratory was established in 2008. It currently has five Biomedical Scientists and one member of administration staff.

The main laboratory focus is Immunoassay. The laboratory will source diverse assays from commercial vendors or develop and evaluate new immunoassays if required. The laboratory has some automated assay platforms (Perkin Elmer AutoDELFIA, Siemens Dimension RXL, Diasorin Liaison XL) as well as the capacity to run assays manually using electrochemical luminescence immunoassays from MesoScale Discovey and various ELISA assays. The Tecan Evo 100 robotic sample processing station is use to load samples when required.

Although the laboratory is mainly concerned with ‘research’ assays there is a strong focus on quality control. Well-established protocols are in place for sample receipt, analysis and storage. CBAL issues approximately 100,000 results each year and has a repertoire of over 200 different assays.

CBAL has close links with many Research Groups on the Cambridge Biomedical Campus (CRUK, IMS, LMB), it also works closely with start-up companies in the Cambridge area (ProteinLogic, Urosens) as well as more established partners (Takeda, Sanger). CBAL has also worked with Research groups around the UK in establishments such as UCL & KCL in London, and University departments in Newcastle, Aberdeen and Southampton.

CBAL will expand over the coming year. We are in the process of refurbishing a 2nd laboratory. We have also been successful in bids for equipment for MSIA (Mass Spectrometry – Immunoassay) and Luminex as well as upgrades to many of our older pieces of equipment.

East Anglian Medical Genetics Service- comprises the genetics laboratories (molecular genetics and cytogenetics) and clinical genetics
Genetics Laboratories
- offers cytogenetic (chromosome) and molecular genetic (DNA) analysis
- located within purpose built facilities and are rapidly expanding with more than 40 staff consisting of clinical scientists, biomedical scientists, pre-registration scientists, genetic technologists and administration staff
Clinical Genetics
- highly-skilled multidisciplinary team of doctors, genetic counsellors and clinical scientists provide individuals and families with clinical and laboratory diagnosis of genetic disorders; risk assessment and genetic counselling for patients who have a family history of an inherited disorder or a family cancer syndrome; predictive genetic testing including prenatal diagnosis for some genetic disorders
- service is based at Addenbrooke's with clinics held in hospitals around the region
Haematology Translational Research Laboratory- NIHR Cambridge BRC funding has been used to refurbish space in the NHS Blood and Transplant Centre to create a Haematology Translational Research Laboratory
Histocompatibility and Immunogenetics (Tissue Typing) Laboratory The Cambridge University Hospital’s Histocompatibility and Immunogenetics (Tissue Typing) Laboratory provides specialist histocompatibility and immunogenetics services for the East of England and is part of the NIHR Cambridge Biomedical Research Centre. We offer a comprehensive range of molecular and serological techniques to identify Human Leukocyte Antigen (HLA) polymorphism, Killer Cell Immunoglobulin-Like Receptor (KIR) typing and immunological allosensitisation to HLA. These tests are performed in support of the regional solid organ and stem cell transplant programmes, in the differential diagnosis of HLA associated diseases and in pharmacogenomics (adverse drug reactions).
Biochemical Genetics Unit- based at Addenbrooke’s Hospital
- provides laboratory services for the investigation and monitoring of inborn errors of metabolism
- service includes newborn screening of approximately 28,000 babies born in East Anglia per annum - screened for phenylketonuria (PKU), congenital hypothyroidism (CHT), cystic fibrosis (CF), sickle cell disease (SCD) and medium chain acyl-CoA dehydrogenase deficiency (MCADD)
- laboratory also provides core metabolic tests supporting the metabolic (adult and paediatric), genetic and neurology clinics both locally at Addenbrooke’s and across the region
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